Severe Malaria Not Responsive to Artemisinin Derivatives in Man Returning from Angola to Vietnam
نویسندگان
چکیده
Resistance to artemisinin derivatives, the most potent antimalarial drugs currently used, has emerged in Southeast Asia and threatens to spread to Africa. We report a case of malaria in a man who returned to Vietnam after 3 years in Angola that did not respond to intravenous artesunate and clindamycin or an oral artemisinin-based combination.
منابع مشابه
Severe Malaria Not Responsive to Artemisinin Derivatives in Man Returning from Angola to Vietnam
Severe malaria not responsive to artemisinin derivatives in man returning from Angola to Vietnam. In Response: We agree with Ringwald and Dondorp (1) that our report of a Vietnamese worker returning from An-gola with severe Plasmodium falciparum malaria not responsive to artemisinins (2) is unlikely to indicate that artemisinin resistance has reached Angola. Nevertheless, this case, for its unu...
متن کاملClinical Pharmacology of the Antimalarial Artemisinin-Based Combination and other Artemisinins in Children
In 2010, there were estimated 219 million cases of malaria resulting in 666,000 deaths and two-thirds were children. Children are more vulnerable than adults to malaria parasites. In sub-Saharan African countries, maternal malaria is associated with up to 200,000 estimated infant deaths yearly. Malaria is caused by five Plasmodium parasites namely: Plasmodium falciparum, Plasmodium vivax, Plasm...
متن کاملArtemisinin derivatives for treating severe malaria.
BACKGROUND Artemisinin derivatives may have advantages over quinoline drugs for treating severe malaria since they are fast acting and effective against quinine resistant malaria parasites. OBJECTIVES The objective of this review was to assess the effects of artemisinin drugs for severe and complicated falciparum malaria in adults and children. SEARCH STRATEGY We searched the Cochrane Infec...
متن کاملArtesunate Misuse and Plasmodium falciparum Malaria in Traveler Returning from Africa
Plasmodium falciparum malaria developed in an African-born traveler who returned to Canada after visiting Nigeria. While there, she took artesunate prophylactically. Isolates had an elevated 50% inhibitory concentration to artemisinin, artesunate, and artemether, compared with that of other African isolates. Inappropriate use of artemisinin derivatives can reduce P. falciparum susceptibility.
متن کاملMisuse of Artemisinin Combination Therapies by Clients of Medicine Retailers Suspected to Have Malaria Without Prior Parasitological Confirmation in Nigeria
Background Prompt and effective case detection and treatment are vital components of the malaria case management strategy as malaria-endemic countries implement the testing, treating and tracking policy. The implementation of this policy in public and formal private sectors continue to receive great attention while the informal private retail sector (mostly the patent and propriety medicine ven...
متن کامل